Embark on a scenic road trip from Cape Girardeau, Missouri, to Fayetteville, Arkansas, and explore many historic landmarks, museums, and parks that capture the essence of the American Midwest. This journey spans over 281 miles and offers an array of experiences for the road trip enthusiasts.

This article discusses the cost of a trip between Cape Girardeau, Missouri, and Fayetteville, Arkansas based on different routes and current gas prices. It provides recommendations and concludes with an overview of the trip's length and features.

Take a road trip from Cape Girardeau, Missouri to Fayetteville, Arkansas! Explore the Midwest with multiple scenic routes. Read on for estimated driving times and notable stops.