Discover the top five places to visit on a road trip spanning over 2,600 miles from Buffalo, New York, to Nogales, Arizona, including Niagara Falls, the Grand Canyon, and Zion National Park.

Planning a road trip from Buffalo, NY to Nogales, AZ? Explore different routes, cost, and distance options in this article. Learn the best route for scenic views and estimated gas prices for a budget-friendly trip.

Take a road trip from Buffalo, NY to Nogales, AZ and explore the different routes. Enjoy exciting destinations, landmarks, and beaches on the way. Get recommendations for pitstops and stay safe, hydrated, and entertained.