Discover the top places to visit on a road trip from Bluffton, South Carolina, to Sioux Falls, South Dakota! From national parks to iconic landmarks, this list will guide you through an unforgettable journey.

Planning a road trip from Bluffton, SC to Sioux Falls, SD? Read on for cost comparisons of three routes and factors to consider when budgeting for gas, food, and lodging.

Plan your next road trip from Bluffton, SC to Sioux Falls, SD. Discover scenic routes, distance, travel time, and recommended stops along the way. Happy travels!