Experience the best of the Carolinas on a road trip from Durham to Greenville. Discover NASCAR history, thrilling amusement parks, historic charm, scenic parks, and outdoor adventures along the way. Embark on a journey filled with culture, history, and unforgettable experiences.

Planning a road trip from Durham, NC, to Greenville, SC? Discover the cost breakdown of three different routes including distance, time, and estimated gas prices based on current rates. Choose the best option for your travel budget and timeline!