Explore the road trip from Durham, NC, to Ithaca, NY, with stops at iconic landmarks like the National Mall and Antietam Battlefield. Discover museums, parks, and more along the 500-mile route, making for a memorable journey through American history and natural beauty.

Discover the best route from Durham, NC, to Ithaca, NY, based on gas prices. Compare costs and distances for different routes to optimize your travel budget.