Discover five unexpected stops on a road trip from Dupo, Illinois, to Anderson, South Carolina. From Shawnee National Forest to Nashville and more, explore hidden gems and local flavors along the way!

Discover the cost-effective road trip route from Dupo, Illinois, to Anderson, South Carolina, via I-65 S and I-85 S. Explore fuel costs, distances, and travel tips for a smooth journey through the heart of the Midwest and Southeast.