Discover the best stops on a road trip from DeSoto, Texas, to Saint Louis, Missouri, including Afton Station and the Gateway Arch. Explore art, nature, and history along this 400-mile journey.

Planning a road trip from DeSoto, Texas, to Saint Louis, Missouri? Learn about the best route options, current gas prices, and cost breakdowns to help you budget effectively.

Embark on a road trip from DeSoto, Texas to St. Louis, Missouri with various route options and fun stops along the way! Discover scenic drives, recommended pit stops, and approximate driving times for an exciting journey. Pack your bags and hit the road for a memorable adventure!