Embark on a road trip from De Soto, Missouri to Maryville, Illinois, with stops at must-see attractions along the way. From underground caves to historic sites, explore the top five places to visit on this exciting journey.

Planning a trip from De Soto, MO to Maryville, IL? Learn the cost breakdown of driving routes, distances, times, and gas prices to help you budget wisely.

Embark on a road trip from De Soto, Missouri, to Maryville, Illinois, with insights on the fastest routes, traffic patterns, and optimal travel times. Whether you prefer a scenic drive or a quick journey, this guide has you covered. Plan your adventure today!