Embark on a 1100-mile road trip from De Pere, Wisconsin to Smithfield, North Carolina, featuring top attractions like the Rock & Roll Hall of Fame and the Smoky Mountains National Park. Discover the best stops along the route for a memorable adventure through the Midwest and the South.

Embark on a road trip from De Pere, Wisconsin to Smithfield, North Carolina. Explore different routes, costs, and distances based on current gas prices. Choose the best option for your budget and travel preferences. Happy driving!

Planning a road trip from De Pere, WI, to Smithfield, NC? Discover the fastest and most scenic routes, drive times at peak and off-peak hours, and tips for a hassle-free journey.