Discover museums, parks, and landmarks on a road trip from Darlington to Charleston. Explore historical sites and scenic stops along the 110-mile journey through South Carolina. Drive time approximately 2 hours.

Plan your road trip from Darlington to Charleston, SC! Discover route options, costs, and recommended paths based on current gas prices. Maximize your travel experience while saving on expenses.

Discover the best routes and driving times from Darlington to Charleston, South Carolina. Plan your journey wisely to avoid traffic and enjoy the scenic views along the way!