Embark on an unforgettable road trip from Columbia, South Carolina to St. Joseph, Illinois, exploring breathtaking landscapes, iconic landmarks, and historic sites along the way. Don't miss the top five must-see attractions, including the Blue Ridge Parkway and the Gateway Arch!

Planning a trip from Columbia, SC to St. Joseph, IL? Discover the most cost-effective route for your journey with our comprehensive guide on gas prices and travel options.

Embark on an epic road trip from Columbia, SC to St. Joseph, IL with different routes, distances, and travel times highlighted. Discover hidden gems and recommended stops along the way for a fun and unforgettable journey. Start planning your adventure today!