Discover the top museums, parks, and landmarks on a road trip from Columbia, SC to Seneca, SC. Explore the state's history, nature, and unique attractions along a scenic 130-mile route. Don't miss out on the South Carolina State Museum, Congaree National Park, Riverbanks Zoo, Clemson University, and Stumphouse Tunnel.

Discover the most cost-effective route between Columbia and Seneca, SC based on current gas prices. Compare distances, gas prices, and travel times to make the best choice for your trip.

Embark on a road trip adventure from Columbia to Seneca with scenic routes and charming stops along the way. Discover the best way to travel between these two South Carolina cities in this guide.