Discover the best road trip from Columbia, SC to Panama City Beach, FL! Explore Savannah's historic district, visit the World of Coca-Cola, relax on stunning beaches, and more. A memorable journey awaits!

Planning a road trip from Columbia, SC to Panama City Beach, FL? Discover the cost of driving based on current gas prices and toll fees for different routes.

Plan your road trip from Columbia, SC to Panama City Beach, FL with our guide on driving time and routes. Learn the fastest and slowest options and how traffic patterns can impact your journey.