Discover the best things to do on a road trip from Columbia, South Carolina to Lexington, Kentucky. Explore the Biltmore Estate, Great Smoky Mountains, Jack Daniel's Distillery, Mammoth Cave, and the Horse Capital of the World.

Discover the cost-effective route from Columbia, SC to Lexington, KY based on current gas prices. Learn about the different routes and their expenses to plan your trip efficiently.

Embark on a road trip from Columbia, SC to Lexington, KY! Discover scenic routes, pit stops, and estimated driving times for a fun and memorable adventure.