Embark on an epic road trip from Columbia, SC to Islamorada, FL. Discover historic Savannah, magical St. Augustine, and beautiful beaches along the way. Get ready for a journey filled with adventure and natural wonders.

Plan your road trip from Columbia, SC to Islamorada, FL with our cost breakdown based on current gas prices and tolls. Choose the route that fits your budget!

Embark on an exciting road trip adventure from Columbia, SC to Islamorada, FL with our guide to different routes, distances, and travel times. Discover scenic pit stops and unique attractions along the way!