Embark on an unforgettable road trip from Columbia, Missouri to Vienna, West Virginia, and explore the top must-visit places along the way. From enchanting small towns to scenic landscapes, discover the hidden gems of the Midwest and Appalachia on this epic journey.

Planning a road trip from Columbia, MO to Vienna, WV? Learn about the costs of driving, distances, times, and potential tolls to help you budget for your journey.

Embark on a road trip from Columbia, MO to Vienna, WV! Discover the fastest, scenic, and adventurous routes with recommended pit stops along the way. Join us for an unforgettable journey through the Midwest to the Appalachian region.