Embark on a thrilling road trip from Columbia, Missouri to Tuscaloosa, Alabama, exploring hidden gems like the Ozark National Scenic Riverways and the historic Muscle Shoals Sound Studio. Discover the best things to do and be captivated by the beauty of nature, literary history, and vibrant culture along the way.

Discover the cost of a trip between Columbia, Missouri and Tuscaloosa, Alabama based on current gas prices. Compare different routes and find the most affordable option for your journey.

Plan your road trip from Columbia, MO to Tuscaloosa, AL with our guide on the fastest and most scenic routes, driving distances, and estimated travel times. Discover the best route for your journey!