Embark on a captivating road trip from Columbia, MO to O'Fallon, MO, exploring iconic landmarks like Mark Twain's birthplace and the Gateway Arch, while indulging in nature, history, and local charm along the way. A perfect Midwest getaway awaits!

Planning a road trip from Columbia, Missouri to O’Fallon, Missouri? Learn about the cost of driving based on current gas prices for different routes. Save money on gas with our breakdown!

Discover the best routes from Columbia to O’Fallon, Missouri, and the drive times for each option. Get recommendations for scenic stops along the way in this fun road trip guide through the Show-Me State.