Embark on an unforgettable road trip from Columbia, Missouri to Alexandria, Virginia. Explore iconic attractions like the Gateway Arch, Mammoth Cave, Harpers Ferry, Mount Vernon, and Great Falls Park. Discover historical landmarks and breathtaking natural wonders along the way.

Planning a trip from Columbia, Missouri to Alexandria, Virginia? Discover the most cost-effective route based on gas prices and distance, and make the most of your journey.

Discover the best routes from Columbia, Missouri to Alexandria, Virginia with approximate distances and driving times. Explore scenic stops along the way for an unforgettable road trip experience.