Embark on an epic road trip from Columbia, Maryland to Port Saint Lucie, Florida, and discover the best attractions along the East Coast. Explore historic Williamsburg, the Great Smoky Mountains, Myrtle Beach, Savannah, and art-filled St. Augustine. Plan your unforgettable adventure now!

Planning a road trip from Columbia, Maryland to Port Saint Lucie, Florida? Discover the cost of driving, distance, and time for different routes with current gas prices and tolls.

Embark on a road trip from Columbia, MD to Port Saint Lucie, FL! Discover the best routes, travel times, and recommended stops along the way for an unforgettable adventure through the East Coast.