Discover the top museums, parks, and landmarks on a road trip from Columbia, Maryland to Knoxville, Tennessee. Visit the Pennsylvania State Capitol, Natural Bridge State Park, Great Smoky Mountains National Park, Dollywood, and Knoxville Museum of Art. Find out more!

Planning a trip between Columbia, MD, and Knoxville, TN? Learn about the cost-effective route based on current gas prices and distance analysis. Travel smart and save on your journey.

Planning a road trip from Columbia, Maryland to Knoxville, Tennessee? Discover the fastest and slowest routes, drive times based on traffic patterns, and alternate options in this helpful guide.