Discover the top museums, parks, and landmarks on a road trip from Clarksville, Tennessee to Columbia, South Carolina. From the stunning Great Smoky Mountains National Park to the historic Biltmore Estate, explore hidden gems along this scenic route.

Planning a trip from Clarksville, Tennessee to Columbia, South Carolina? Discover the cost of your journey based on current gas prices. Find the best route and estimate the travel duration.

Planning a road trip from Clarksville, Tennessee to Columbia, South Carolina? Discover the fastest and slowest routes, driving times based on traffic patterns, and various options for a scenic drive in this helpful guide.