Plan your road trip from Chicago, Illinois to Saint Charles, Missouri with our top five must-visit destinations along the way. From iconic landmarks to outdoor adventures, there's something for everyone on this route.

Planning a trip from Chicago to Saint Charles? Discover the cost of different routes based on today's gas prices, and find the most efficient way to travel between these two destinations.

Embark on an exciting road trip from Chicago to Saint Charles! Discover the different routes, distances, and estimated travel times, along with recommended pit stops along the way. Get ready for an unforgettable Midwest adventure!