Discover five unexpected places to stop on a drive from Chicago, IL, to Columbia, SC, including foodie hotspots in Louisville and Greenville, and Asheville's scenic beauty.

Planning a trip from Chicago, Illinois to Columbia, South Carolina? Discover the costs and distances of different routes in this comprehensive guide, and find the most economical and efficient option for your journey.

Planning a road trip from Chicago to Columbia? Discover the fastest and slowest routes, their distances, and estimated driving times based on traffic patterns. Get ready for an unforgettable adventure!