Discover five unexpected places along the drive from Chicago, Illinois to Charleston, South Carolina, including Mammoth Cave, Asheville, and Hilton Head. Find out where to eat and what to do at each location.

Planning a road trip from Chicago to Charleston? Find out the cost of each route and choose the best based on current gas prices. Discover the scenic or fastest options for an enjoyable journey.

Embark on an epic road trip from Chicago to Charleston with our guide. Discover the fastest and most scenic routes, along with estimated driving times for peak and low traffic. Get ready for an unforgettable adventure!