Discover the top five best places to visit on a road trip between Charleston, SC and Winston-Salem, NC. Explore national parks, zoos, historic downtowns, state parks, and living history museums on this epic journey.

Planning a road trip from Charleston, SC to Winston-Salem, NC? Save time and money with our cost comparison of different routes. Find the most affordable option for your budget.

Planning a road trip from Charleston, SC to Winston-Salem, NC? Discover the fastest and most scenic routes, along with drive times based on traffic patterns. Find the route that suits you best!