Discover the top five must-visit destinations on a road trip from Charleston to Naples. From the oldest city in the US to the ultimate beach town, this scenic route has it all.

Planning a road trip between Charleston and Naples? Read this article to learn about the cost and various routes to choose from, plus tips on how to save on other travel expenses.

Embark on an unforgettable road trip from Charleston, SC, to Naples, FL, uncovering scenic routes, estimated travel times, and must-visit pit stops along the way. Get ready for an adventure of a lifetime!