Discover the top five places to visit between Charleston, South Carolina, and Knoxville, Tennessee. From historic mansions to natural wonders, this road trip has it all!

Planning a road trip from Charleston, SC to Knoxville, TN? Check out this post to find out how much it'll cost to drive each route based on current gas prices.

Embark on an unforgettable road trip from charming Charleston, SC to vibrant Knoxville, TN. Choose from scenic routes, discover recommended stops, and experience the beauty of the southern United States on this epic adventure!