Discover the top five popular attractions to see on a road trip between Charleston, SC, and Indianapolis, IN. From timeless historic landmarks to natural wonders, this itinerary features the best of the South and the Midwest.

Planning a road trip from Charleston, SC to Indianapolis, IN? This post highlights different routes, distances, time, and costs based on current gas prices and toll prices.

Planning a road trip from Charleston, SC to Indianapolis, IN? Discover the fastest and slowest routes, driving times during peak and low traffic, and choose the best option for your adventure.