Discover five unexpected and fascinating stops on a scenic road trip from Charleston, South Carolina to Florence, Kentucky, featuring must-try foods and exciting activities along the way.

Planning a trip from Charleston, SC to Florence, KY? Check out our cost estimates for different routes based on gas and toll prices. Find your perfect road trip now!

Embark on an epic road trip from Charleston, SC to Florence, KY! Discover the best routes, drive times, and must-visit stops along the way. Get ready for a memorable adventure through stunning landscapes and vibrant cities.