Explore the top five places to visit on a road trip from Charleston, SC, to Chicago, IL, including the Great Smoky Mountains and the Rock and Roll Hall of Fame. Discover the beauty and history of America's eastern coast and Midwest.

Planning a road trip from Charleston to Chicago? Check out this guide for estimated gas costs and toll prices for the different routes available to you!

Embark on an epic road trip from Charleston to Chicago! Discover scenic routes, distance, and drive times, along with recommended pit stops and attractions along the way. Get ready for an unforgettable adventure!