Discover the top five popular attractions to see on a road trip between Cayce, South Carolina, and St. Louis, Missouri. Explore Mammoth Cave National Park, Land Between the Lakes National Recreation Area, The Gateway Arch, City Museum, and Silver Dollar City on this exciting journey.

Planning a road trip from Cayce, SC to St. Louis, MO? Find out the cost and possible routes to take with our detailed guide, along with tips to save money on gas.

Planning a road trip from Cayce, SC to St. Louis, MO? Check out this guide for the fastest and slowest routes, distance, and peak and low traffic times to save you time and hassle on the road.