Discover the top five things to do on an exciting road trip from Cary, NC to Little River, SC. Explore historic landmarks, beautiful beaches, quaint towns, and unique attractions along the way.

Here, we break down the cost of driving from Cary, North Carolina to Little River, South Carolina along four different routes based on current gas prices and tolls.

Embark on a Southern adventure and hit the road from Cary, North Carolina, to Little River, South Carolina with this guide. Discover four different routes, distance and time for each one, and recommendations for stops along the way.