Discover five unexpected places to stop on a road trip from Carmel, Indiana to Winston-Salem, North Carolina, including the "Home of the Mothman" in Point Pleasant, WV, and the world's longest cave system in Kentucky's Mammoth Cave National Park.

Planning a road trip from Carmel, Indiana, to Winston-Salem, North Carolina? Check out this detailed breakdown of the cost and distance for each possible route to find the best one for your budget.

Explore the different routes from Carmel, IN to Winston-Salem, NC! From picturesque mountain drives to exploring Southern charm, this road trip has it all. Read on for driving times, distance, and recommendations for places to stop along the way.