Discover five unexpected places to stop on a scenic road trip from Carlisle to Danville, including the oldest brewery in America and a charming historic hotel.

Planning a trip from Carlisle to Danville? Check out the cost breakdown for each possible route and make an informed decision based on current gas prices and travel time.

Plan your road trip right with our driving guide from Carlisle to Danville, PA. Discover the fastest, most scenic, and best times to take for your travels.