Discover the top five places to visit on a road trip from Cape Girardeau, Missouri to Panama City Beach, Florida, including iconic landmarks, historic districts, and exciting marine shows at the Gulf World Marine Park.

Planning a road trip from Cape Girardeau, Missouri to Panama City Beach, Florida? Learn the cost and distance of three possible routes and choose the best one based on your budget.

Plan a road trip from Cape Girardeau to Panama City Beach. Explore the different scenic routes to take, with driving times and recommendations for stops along the way.