Ready for a road trip? Explore museums, parks, and landmarks on the scenic drive from Cape Girardeau, MO to Owensboro, KY. Discover the top five must-see destinations on this 4-hour adventure.

Discover the estimated cost of driving from Cape Girardeau, Missouri, to Owensboro, Kentucky, including gas and toll prices, with different routes to choose from.

Discover the time it takes to drive from Cape Girardeau, Missouri to Owensboro, Kentucky with this guide. Find the fastest and slowest routes and driving times during peak and low traffic times.