Discover the top five things to do on a road trip from Cape Girardeau, Missouri, to Orange Beach, Alabama, including Mammoth Cave and the Natchez Trace Parkway. Uncover interesting facts about each location and plan the ultimate Southern adventure.

Planning to go from Cape Girardeau, MO to Orange Beach, AL? Check out our article to learn about the different routes to take, associated costs, and our recommended route to help you save money on gas.

This blog post lists the fastest and slowest routes for driving from Cape Girardeau, Missouri to Orange Beach, Alabama. It includes estimated driving time in peak and low traffic for each route.