Take a road trip from Cape Girardeau, Missouri to Memphis, Tennessee and explore museums, parks, and landmarks along the Mississippi River. Discover top destinations and must-see points of interest in this comprehensive guide.

Explore the cost of a road trip from Cape Girardeau, MO to Memphis, TN on different routes. Choose the best route and enjoy a scenic ride through Midwestern areas.

Discover the best routes for a road trip from Cape Girardeau to Memphis. Choose from scenic, foodie or historical routes, enjoy the drive and experience Memphis’ finest attractions.