Explore the best attractions on a road trip from Cape Girardeau, Missouri to Columbus, Ohio including the famous Kentucky Derby Museum and the beautiful Hocking Hills State Park. Discover what else this adventure-filled 520-mile journey has to offer.

Planning a road trip from Cape Girardeau, MO to Columbus, OH? Check out the different routes with distances, times, and costs breakdown to stick to your budget.

Plan your road trip from Cape Girardeau to Columbus with these helpful tips. Explore the best routes, estimated driving times, and recommended stops along the way.