Discover the top 5 things to do on a road trip from Cape Girardeau, MO to Clarksville, TN. From national parks to live music, experience the best sights on this 290-mile journey.

Discover the cost of driving from Cape Girardeau, MO, to Clarksville, TN, based on current gas prices. Learn about the distance, time, and cost of each route with no tolls.

Plan your road trip from Cape Girardeau to Clarksville with this guide on the time it takes to drive, the different routes available and the distance covered.