Discover five unexpected places to stop on a road trip from Cape Girardeau, Missouri, to Cheyenne, Wyoming. From historic landmarks to picturesque towns, embark on an enriching journey through the heartland of America.

Planning a road trip from Cape Girardeau, MO to Cheyenne, WY? Discover the most cost-effective routes and fuel expenses for each option, and find the optimal way to make your journey.

Embark on an epic road trip from Cape Girardeau, Missouri to Cheyenne, Wyoming. Discover two scenic routes, must-see attractions, and estimated travel times. Buckle up and get ready for adventure!