Discover the top five must-see attractions on a road trip from Cape Girardeau to Beaufort. Explore Mammoth Cave, Margaritaville Resort, Stone Mountain, Myrtle Beach, and Charleston. Find the best route and plan your adventure today!

This blog post breaks down the cost of driving from Cape Girardeau, Missouri to Beaufort, South Carolina based on current gas prices and various routes. Learn how to budget for gas and tolls and pick the most cost-effective route for your road trip.

Planning a road trip from Cape Girardeau, MO to Beaufort, SC? Check out our breakdown of the best routes, distances, drive times, and must-see stops for each option. Discover the most scenic views and hidden gems to make your journey unforgettable.