Discover the top five best places to visit on a road trip between Cape Coral and Saint Petersburg, including Sanibel Island, Sarasota, and Ybor City.

Planning a road trip from Cape Coral to St. Petersburg, Florida? Check out our guide on the cost of each route based on current gas prices and toll fees. Safe travels!

Discover the top 3 routes to travel from Cape Coral to Saint Petersburg in Florida. Explore the scenic options and plan a fun road trip with our estimated driving times and recommendations for must-visit stops.