Discover the top five must-visit places on a road trip between Canton, Missouri and Tuscaloosa, Alabama. From charming small towns to vibrant cities, this journey through the Midwest and the Deep South has it all.

Planning a road trip from Canton, Missouri to Tuscaloosa, Alabama? Check out our cost comparison of different routes to help you choose the best option for your budget.

Discover the best routes, distances, and travel times between Canton, MO and Tuscaloosa, AL. Explore fun pit stops and recommended places to visit along the way.