Discover unexpected places to visit on a road trip from Buffalo, NY to Waltham, MA. Explore museums, natural beauty, and historic villages, and indulge in some delicious eats along the way.

Planning a trip between Buffalo, NY, and Waltham, MA? Our article breaks down the costs and distances of the different routes, so you can choose the most affordable option based on current gas prices.

Discover the best routes and travel times to get from Buffalo, New York to Waltham, Massachusetts for a New England adventure. Read our recommendations for places to stop along the way!