Discover the must-visit places between Buffalo and Depew, NY, with our top five picks. From living museums to amusement parks, there's something for everyone!

Discover the cost of driving from Buffalo, NY, to Village of Depew, NY, based on current gas and toll prices. Explore different routes to find the cheapest, quickest or less-crowded option.

Planning a road trip from Buffalo to Village of Depew, New York? Check out our guide to the different routes, drive times, and fun stops along the way!