Experience the adventure of a road trip from Buffalo, NY to St. Louis, MO, and explore top attractions like Niagara Falls, the Rock and Roll Hall of Fame, and the Gateway Arch.

Planning a road trip from Buffalo, NY to St. Louis, MO? Check out this post for a breakdown of the cost of driving based on current gas prices for different routes available.

Get ready for an epic road trip from Buffalo to St. Louis! Explore different routes, drive times, and recommended stops along the way. Discover America's heartland on an unforgettable journey.