Discover the best places to visit on a road trip between Buffalo, NY and Sims, NC. From Niagara Falls to Charleston, explore five amazing destinations in the eastern US.

This article analyzes the cost of a road trip between Buffalo, New York, and Sims, North Carolina. It compares two options based on gas prices and recommends the best route.

Planning a road trip from Buffalo, NY to Sims, NC? This guide breaks down the fastest and slowest routes, distances, and expected driving times based on traffic patterns.