Discover the best things to do on a road trip from Buffalo, New York, to Portland, Maine, including visiting Niagara Falls and Acadia National Park. Explore diverse landscapes, historic landmarks, and vibrant modern culture on this eight-hour journey.

Planning a road trip from Buffalo to Portland? Check out our breakdown of different routes, toll costs, gas prices, and driving times to help you plan your trip and budget accordingly.

Discover three unique routes for a road trip from Buffalo, NY to Portland, ME and the best places to stop along the way. Experience the northeast like never before!